Session S55a (Monday, 5:15pm, Willaman Gateway)

P342: Mass spectrometry across the curriculum

Pamela Seaton (University of North Carolina-Wilmington, USA), Heather Corpus (University of North Carolina-Wilmington, USA), Ralph Mead (University of North Carolina-Wilmington, USA), Emmanuel Hatzakis (University of North Carolina-Wilmington, USA),  Michael Webb (University of North Carolina-Wilmington, USA)

Mass spectrometry (MS) is infused into four courses at UNCW, allowing percolation of this powerful technique through out undergraduate and graduate curricula.  Sophomore organic experiments use MS in determination of molecular formulas of unknown alkanes. Students use classical functional group fragmentation mechanisms to identify structures of their synthetic products.  In our advanced organic lab, students determine molecular formulas of unknowns from their accurate mass using workstations dedicated to MS teaching applications.  Analysis of fragments also allows students to elucidate their Williamson ether and Heck reaction product structures. In our instrumental analysis lab, students compare  resolutions of cetirizine molecular ions afforded by QTOF vs ion trap MS instruments and analyze MS/MS fragmentation.  Our advanced undergraduate/graduate lab students use hands on optimization of mass spectral parameters for accurate mass determination and multidimensional MSn analysis of a variety of small and large molecules, including polyphenols in tea, peptides and triglycerides.

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