Session S51b (Tuesday, 2pm, Thomas 118)

P593: Interactive HPLC simulation: A free, new tool for studying liquid chromatography

Megan Nagel (Pennsylvania State University – Greater Allegheny, USA), Paul Boswell (University of Minnesota, USA), Dwight Stoll (Gustavus Adolphus College, USA), Mark Vitha (Drake University, USA)

To fill a present need for an HPLC simulation resource that is user-friendly, inexpensive, and mimics the sophistication of current instrumentation, a free, open-source, educational tool has been developed at  The intuitive controls offered by this site allow the user to easily adjust a wide number of experimental parameters, including temperature, flow rate, and column properties, and immediately observe the impact of any changes on the provided chromatogram.    The simulator is simple enough for a beginner, yet offers a depth of complexity to challenge the more advanced user.   A help menu, tutorials, and a number of sample classroom activities are available for use on the site.  The initial results of implementing the HPLC simulator into an undergraduate Quantitative Analysis course showed an increase in both content knowledge and confidence in the area of HPLC versus students not given access to the simulator.


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