Session S55b (Tuesday, 5:15pm, Willaman Gateway)

P608: Memory conversion: Connecting new molecular evidence with models for learning

Reese Gregory (University of Colorado-Denver, USA), Joanna Manatt-Schottleutner (University of Colorado-Denver, USA), Karen Knaus (University of Colorado-Denver, USA)

In recent years, researchers’ increased understanding of neurochemical mechanisms have allowed for more elaborate proposals of the conversion pathways for memory formation and retention.  Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Ga-mediated GTP hydrolysis (‘‘GTPase-accelerating proteins’’ or GAPs) (1).  Recent studies of the visual cortex found that layer 6 neurons of area V2 are crucial for the processing of object-recognition memory (ORM) and that the expression of the protein regulator of G protein signaling–14 (RGS-14) into this specific region promoted the conversion of a normal short-term ORM into long term memory (2). We propose that further exploration of the role of RGS-14 in this conversion may aid in studying the “feedback loop” between perception and long-term memory – the key feature of Alex Johnstone’s information-processing model for learning (3, 4).

1.Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, et al. (2009) Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector. PLoS ONE 4(3): e4884.

doi:10.1371/journal.pone.0004884.

2. López-Aranda, Manuel F., et al. Science. 2009, 325, 87-89.

3. Johnstone, A. H. J. Chem. Educ. 1983, 60, 968–971.

4. Johnstone, A. H. J. Chem. Educ. 1997, 74, 262–268.

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