Session S55b (Tuesday, 5:15pm, Willaman Gateway)

P608: Memory conversion: Connecting new molecular evidence with models for learning

Reese Gregory (University of Colorado-Denver, USA), Joanna Manatt-Schottleutner (University of Colorado-Denver, USA), Karen Knaus (University of Colorado-Denver, USA)

In recent years, researchers’ increased understanding of neurochemical mechanisms have allowed for more elaborate proposals of the conversion pathways for memory formation and retention.  Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Ga-mediated GTP hydrolysis (‘‘GTPase-accelerating proteins’’ or GAPs) (1).  Recent studies of the visual cortex found that layer 6 neurons of area V2 are crucial for the processing of object-recognition memory (ORM) and that the expression of the protein regulator of G protein signaling–14 (RGS-14) into this specific region promoted the conversion of a normal short-term ORM into long term memory (2). We propose that further exploration of the role of RGS-14 in this conversion may aid in studying the “feedback loop” between perception and long-term memory – the key feature of Alex Johnstone’s information-processing model for learning (3, 4).

1.Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, et al. (2009) Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector. PLoS ONE 4(3): e4884.


2. López-Aranda, Manuel F., et al. Science. 2009, 325, 87-89.

3. Johnstone, A. H. J. Chem. Educ. 1983, 60, 968–971.

4. Johnstone, A. H. J. Chem. Educ. 1997, 74, 262–268.


A sample text widget

Etiam pulvinar consectetur dolor sed malesuada. Ut convallis euismod dolor nec pretium. Nunc ut tristique massa.

Nam sodales mi vitae dolor ullamcorper et vulputate enim accumsan. Morbi orci magna, tincidunt vitae molestie nec, molestie at mi. Nulla nulla lorem, suscipit in posuere in, interdum non magna.